by Dr. Steven Best
Abstract: As the debates over cloning and stem cell research indicate, issues raised by biotechnology combine research into the genetic sciences, perspectives and contexts articulated by the social sciences, and the ethical and anthropological concerns of philosophy. Consequently, I argue that intervening in the debates over biotechnology requires supra-disciplinary critical philosophy and social theory to illuminate the problems and their stakes. In addition, debates over cloning and stem cell research raise exceptionally important challenges to bioethics and a democratic politics of communication.
Anyone who thinks that things will move slowly is being very naive. –Lee Silver, Molecular Biologist
As we move into a new millennium fraught with terror and danger, a global postmodern condition is unfolding in the midst of rapid evolutionary and social changes co-constructed by science, technology, and the restructuring of global capital. We are quickly morphing into a new biological and social existence that is ever-more mediated and shaped by computers, mass media, and biotechnology, all driven by the logic of capital and a powerful emergent technoscience. In this global context, science is no longer merely an interpretation of the natural and social worlds; rather it has become an active force in changing them and the very nature of life. In an era where life can be created and redesigned in a petridish, and genetic codes can be edited like a digital text, the distinction between ‘‘natural’’ and “artificial’’ has become greatly complexified. The new techniques of manipulation call into question existing definitions of life and death, demand a rethinking of fundamental notions of ethics and moral value, and pose unique challenges for democracy.
As technoscience develops by leaps and bounds, and as genetics rapidly advances, the science–industrial complex has come to a point where it is creating new transgenic species and is rushing toward a posthuman culture that unfolds in the increasingly intimate merging of technology and biology. The posthuman involves both new conceptions of the ‘‘human’’ in an age of information and communication, and new modes of existence, as flesh merges with steel, circuitry, and genes from other species. Exploiting more animals than ever before, techno-science intensifies research and experimentation into human cloning. This process is accelerated because genetic engineering and cloning are developed for commercial purposes, anticipating enormous profits on the horizon for the biotech industry. Consequently, all natural reality—from microorganisms and plants to animals and human beings—is subject to genetic reconstruction in a commodified ‘‘Second Genesis.’’
At present, the issues of cloning and biotechnology are being heatedly debated in the halls of science, in political circles, among religious communities, throughout academia, and more broadly in the media and public spheres. Not surprisingly, the discourses on biotechnology are polarized. Defenders of biotechnology extol its potential to increase food production and quality, and to cure diseases, endow us with ‘‘improved’’ human traits, and prolong human life. Its critics claim that genetic engineering of food will produce Frankenfoods, which pollute the food supply with potentially harmful products that could devastate the environment, biodiversity, and human life itself; that animal and human cloning will breed monstrosities; that a dangerous new eugenics is on the horizon; and that the manipulation of embryonic stem cells violates the principle of respect for life and destroys a bona fide ‘‘human being.’’
Interestingly, the same dichotomies that have polarized information-technology discourses into one-sided technophobic and technophillic positions are reproduced in debates over biotechnology. Just as I believe that critical theories of technology are needed to produce more dialectical perspectives that distinguish between positive and negative aspects and effects of information technology (Best and Kellner 2001), so too I would claim that similar approaches are required to articulate the potentially beneficial and perhaps destructive aspects of biotechnology. Indeed, current debates over cloning and stem cell research suggest powerful contradictions and ambiguities in these phenomena that render one-sided positions superficial and dangerous. Parallels and similar complexities in communication and biotechnology are not surprising given that information technology provides the infrastructure to biotechnology that has been constituted by computer-mediated technologies involved in the Human Genome Project, and, conversely, genetic science is being used to push the power and speed of computers through novelties such as ‘‘gene chips.’’
As the debates over cloning and stem cell research indicate, issues raised by biotechnology combine research into the genetic sciences, perspectives and contexts articulated by the social sciences, and the ethical and anthropological concerns of philosophy. Consequently, I argue that intervening in the debates over biotechnology require supra-disciplinary critical philosophy and social theory to illuminate the problems and their stakes. In addition, debates over cloning and stem cell research raise exceptionally important challenges to bioethics and a democratic politics of communication. Biotechnology is thus a critical flashpoint for ethics and democratic theory and practice. Contemporary biotechnology underscores the need for more widespread knowledge of important scientific issues; participatory debate over science, technology, values, and our very concept of human life; and regulation concerning new developments in the biosciences, which have such high economic, political, and social consequences.
New genetic technologies like stem cell research contain positive potential for medical advances that should not be blocked by problematic conservative positions. Nonetheless, I believe that the entire realm of biotechnology is fraught with dangers and problems that require careful study and democratic debate. The emerging genomic sciences should thus be undertaken by scientists with a keen sense of responsibility and accountability, and be subject to intense public scrutiny and open discussion. Finally, in the light of the dangers and potentially deadly consequences of biotechnology, I maintain that the positive potential of biotechnology can be realized only in a new context of cultivating new sensibilities toward nature, engaging in ethical and political debate, and participating in political struggles over biotechnology and its effects.
I. Brave New Barnyard: The Advent of Animal Cloning
The idea is to arrive at the ideal animal and repeatedly copy it exactly as it is. – Dr. Mark Hardy
From its entrenched standpoint of unqualified human superiority, science, typically first targets objects of nature and animals with its analytic gaze and instruments. The current momentous turn toward cloning is largely undertaken by way of animals, although some scientists have already directly focused on cloning human beings. While genetic engineering creates new ‘‘transgenic’’ species by inserting the gene from one species into another, cloning replicates cells to produce identical copies of a host organism by inserting its DNA into an enucleated egg. In a potent combination, genetic engineering and cloning technologies are used together in order, first, to custom design a transgenic animal to suit the needs of science and industry (the distinction is irrevocably blurred) and, second, to mass reproduce the hybrid creation endlessly for profitable peddling in medical and agricultural markets.
Cloning is a return to asexual reproduction and bypasses the caprice of the genetic lottery and random shuffling of genes. It dispenses with the need to inject a gene into thousands of newly fertilized eggs to get a successful result. Rather, much as the printing press replaced the scribe, cloning allows mass reproduction of a devised type, and thus opens genetic engineering to vast commercial possibilities.
Life science companies are poised to make billions of dollars in profits, as numerous organizations, universities, and corporations move toward cloning animals and human stem cells, and patenting the methods and results of their research.
To date, science has engineered a myriad of transgenic animals and has cloned animals such as sheep, calves, goats, bulls, pigs, mice, and cats. Although still far from precise, cloning nevertheless has become routine. What is radically new and startling is not cloning itself, since from 1952 scientists have replicated organisms from embryonic cells. Rather, the new techniques of cloning, or ‘‘nuclear somatic transfer,’’ from adult mammal body cells constitute a new form of animal reproduction. These methods accomplish what scientists long considered impossible—reverting adult (specialized) cells to their original (nonspecialized) embryonic state where they can be reprogrammed to form a new organism. In effect, this startling process creates the identical twin of the adult that provided the original donor cell. This technique was used first to create Dolly, the first mammal cloned from a cell from an adult animal, and subsequently all of her varied offspring.
II. Dolly and Her Progeny
Traditionally, scientists considered cloning beyond the reach of human ingenuity. But when Ian Wilmut and his associates from the Roslin Institute near Edinburgh, Scotland, announced their earth-shattering discovery in March 1997, the ‘‘impossible’’ appeared in the form of a sheep named Dolly, and a ‘‘natural law’’ had been broken. Dolly’s donor cells came from a 6-year-old Finn Dorset Ewe. Wilmut starved mammary cells in a low-nutrient tissue culture where they became quiescent and subject to reprogramming. He then removed the nucleus containing genetic material from an unfertilized egg cell of a second sheep, a Scottish Blackface, and, in a nice Frankenstein touch, fused the two cells with a spark of electricity. After 277 failed attempts, the resulting embryo was then implanted into a third sheep, a surrogate mother who gave birth to Dolly in July 1996.
Many critics said Dolly was either not a real clone or was just a fluke. Yet, less than 2 years after Dolly’s emergence, scientists had cloned numerous species, including mice, pigs, cows, and goats, and had even made clones of clones of clones, producing genetic simulacra in mass batches as in 1931 Huxley (1989a)envisioned happening to human beings in Brave New World. The commercial possibilities of cloning animals were dramatic and obvious for all to behold. Therace was on to patent novel cloning technologies and the transgenic offspring they would engender.
Animals are being designed and bred as living drug and organ factories, as their bodies are disrupted, refashioned, and mutilated to benefit meat and dairy industries. Genetic engineering is employed in biomedical research by infecting animals with diseases that become a part of their genetic make up and are transmitted to their offspring, as in the case of researchers trying to replicate the effects of cystic fibrosis in sheep. Most infamously, Harvard University, with funding from Du Pont, has patented a mouse—OncoMouse —that has human cancer genes built into its genetic make up and are expressed in its offspring (Haraway 1997).
In the booming industry of ‘‘pharming’’ (pharmaceutical farming), animals are genetically modified to secrete therapeutic proteins and medicines in their milk. The first major breakthrough came in January 1998, when Genzyme Transgenics created transgenic cattle named George and Charlie. The result of splicing human genes and bovine cells, they were cloned to make milk that contains human proteins such as the blood-clotting factor needed by hemophiliacs. Co-creator James Robl said, ‘‘I look at this as being a major step toward the commercialization of this [cloning] technology.’’ In early January 2002, the biotech company PPL announced that they had just cloned a litter of pigs, which could aid in human organ transplants. On the eve of the publication of an article by another company, Immerge Bio Therapeutics claimed that they had achieved a similar breakthrough. The new process involved creation of the first ‘‘knockout’’ pigs, in which a single gene in pig DNA is deleted to eliminate a protein that is present in pigs, which is usually violently rejected by the human immune system. This meant that a big step could be made in the merging of humans and animals, and creating animals as harvest-machines for human organs.
Strolling through the Brave New Barnyard, one can find incredible beings that appear normal, but in fact are genetic satyrs and chimera. Cows generate lactoferrin, a human protein useful for treating infections. Goats manufacture antithrombin III, a human protein that can prevent blood clotting, and serum albumin, which regulates the transfer of fluids in the body. Sheep produce alpha antitrypsin, a drug used to treat cystic fibrosis. Pigs secrete phytase, a bacterial protein that enables them to emit less of the pollutant phosphorous in their manure, and chickens make lysozyme, an antibiotic, in their eggs to keep their own infections down.
‘‘BioSteel’’ presents an example of the bizarre wonders of genetic technology that points to the erasure of boundaries between animate and inanimate matter,as well as among different species. In producing this substance, scientists have implanted a spider gene into goats, so that their milk produces a super-strong material—BioSteel—that can be used for bulletproof vests, medical supplies, and aerospace and engineering projects. In order to produce vast quantities of BioSteel, Nexia Biotechnologies intend to house thousands of goats in 15 weapons-storage buildings, confining them in small holding pens.
As we see, animals are genetically engineered and cloned to produce a stock of organs for human transplants. Given the severe shortage of human organs, thousands of patients every year languish and die before they can receive a healthy kidney, liver, or heart. Rather than encouraging preventative medicine and finding ways to encourage more organ donations, medical science has turned to xeno-transplantation, and has begun breeding herds of animals (with pigs as a favored medium) to be used as organ sources for human transplantation.
Clearly, this is a very hazardous enterprise due to the possibility of animal viruses causing new plagues and diseases in the human population (a danger which exists also in pharmaceutical milk). For many scientists, however, the main concern is that the human body rejects animal organs as foreign and destroys them within minutes. Researchers seek to overcome this problem by genetically modifying the donor organ so that they knock out markers in pig cells and add genes that make their protein surfaces identical to those in humans.
Geneticists envision cloning entire herds of altered pigs and other transgenic animals so that an inexhaustible warehouse of organs and tissues would be available for human use. In the process of conducting experiments such as transplanting pig hearts modified with a human gene into the bodies of monkeys, companies such as Imutran have caused horrific suffering, with no evident value to be gained given the crucial differences among species and introducing the danger of new diseases into human populations.
As if billions of animals were not already exploited enough in laboratories, factory farms, and slaughterhouses, genetic engineering and cloning exacerbate the killing and pain with new institutions of confinement and bodily invasion that demand billions more animal victims. Whereas genetic and cloning technologies in the cases described at least have the potential to benefit human beings, they have also been appropriated by the meat and dairy industries for purposes of increased profit through the exploitation of animals via biotechnology. It’s the nightmarish materialization of the H.G. Wells scenario where, in his prophetic 1904 novel, The Food of the Gods, scientists invent a substance that prompts every living being that consumes it to grow to gargantuan proportions (Best and Kellner 2001). Having located the genes responsible for regulating growth and metabolism, university and corporate researchers immediately exploited this knowledge for profit. Thus, for the glories of carcinogenic carnivorous consumption, corporations such as MetaMorphix and Cape Aquaculture Technologies have created massive pigs, sheep, cattle, lobsters, and fish that grow faster and larger than the limits set by evolution.
Amidst the surreality of Wellsian gigantism, cattle and dairy industries are engineering and cloning designer animals that are larger, leaner, and fastergrowing value producers. With synthetic chemicals and DNA alteration, pharmers can produce pigs that mature twice as fast and provide at least twice the normal amount of sows per litter as they eat 25% less feed, and cows that produce at least 40% more milk. Since 1997, at least one country, Japan, has sold cloned beef to its citizens. But there is strong reason to believe that US consumers—already a nation of guinea pigs in their consumption of pharmaceuticals and genetically modified foods—have eaten cloned meat and dairy products. For years, corporations have cloned farmed animals with the express purpose of someday introducing them to the market, and insiders claim that cloned animals already have been clandestinely marketed and consumed. The National Institute of Science and Technology provided two companies, Origen Therapeutics of California, and Embrex of North Carolina,with almost $5 million to fund research into factory farming billions of cloned chickens for mass consumption. With the Food and Drug Administration pondering whether to regulate cloned meat and dairy products, it’s a good bet they are many steps behind an industry determined to increase their profits through biotechnology. The future to come seems to be one of cloned humans eating cloned animals.
While anomalies such as self-shearing sheep and broiler chickens with fewer feathers have already been assembled, some macabre visionaries foresee engineering pigs and chickens with flesh that is tender or can be easily microwaved, and chickens that are wingless so they won’t need bigger cages. The next step would be to just create and replicate animal’s torsos—sheer organ sacks—and dispense with superfluous heads and limbs. In fact, scientists have already created headless embryos of mice and frogs in grotesque manifestations of the kinds of life they can now construct at will.
Clearly, there is nothing genetic engineers will not do to alter or clone an animal. Transgenic ‘‘artist’’ Eduardo Kac, for instance, commissioned scientists at the National Institute of Agronomic Research in France to create Alba, a rabbit that carries a fluorescent protein from a jellyfish and thus glows in the dark. This experiment enabled Mr. Kac to demonstrate his supremely erudite postmodern thesis that ‘‘genetic engineering [is] in a social context in which the relationship between the private and public spheres are negotiated.’’
Although millions of healthy animals are euthanized every year in US animal ‘‘shelters,’’ corporations are working to clone domestic animals, either to bring them back from the dead, or to prevent them from ‘‘dying’’ (such as in the Missyplicity Project, initiated by the wealthy ‘‘owners’’ of a dog who want to keep her alive indefinitely). Despite alternatives to coping with allergies problems and the dangers with cloning animals, Transgenic Pets LLC is working to create transgenic cats that are allergen-free. In 2002, the biotechnology company Genetic Savings and Clone showcased the world’s first cloned cat, named CC, for Carbon Copy. Pandering to animal guardians’ misconceived desires to immortalize their cat, for a price of $50,000 each, Genetic Savings since has cloned additional cats, and hopes to cash in on what could be a booming market in feline simulacra at great risk for health problems and premature aging.
III. Transgenic Travesties
It is a little known fact that the agricultural use of genetics and cloning technologies has produced horrible monstrosities. Transgenic animals often are born deformed and suffer from fatal bleeding disorders, arthritis, tumors, stomach ailments, kidney disease, diabetes, inability to nurse and reproduce, behavioral and metabolic disturbances, high mortality rates, and large offspring syndrome. In order to genetically engineer animals for maximal weight and profit, a Maryland team of scientists created the infamous ‘‘Beltway pig’’ afflicted with arthritis, deformities, and respiratory disease. Cows engineered with bovine growth hormone (rBGH) have mastitis, hoof and leg maladies, reproductive problems, numerous abnormalities, and die prematurely. Giant supermice endure tumors, damage to internal organs, and shorter life spans. Numerous animals born from cloning are missing internal organs such as hearts and kidneys. A Maine lab specialized in breeding sick and abnormal mice that go by macabre names such as Fathead, Fidget, Hairless, Dumpy, and Greasy. Similarly, experiments in the genetic engineering of salmon have led to rapid growth and various aberrations and deformities, with some growing up to ten times their normal body weight (Fox 1999). Cloned cows are ten times more likely to be unhealthy as their natural counterparts. After 3 years of efforts to clone monkeys, Dr. Tanja Dominko fled in disgust from her well-funded Oregon laboratory. Telling cautionary tales of the ‘‘gallery of horrors’’ she experienced, Dominko said that 300 attempts at cloning monkeys produced nothing but freakishly abnormal embryos that contained cells either without chromosomes or with up to nine nuclei.
For Dominko, a ‘‘successful’’ clone like Dolly is the exception, not the rule. But even Dolly became inexplicably overweight and arthritic, and may have been prematurely aging. In February 2003, suffering from progressive lung disease, Dolly was euthanized by her ‘‘creators,’’ bringing to a premature end the first experiment with adult animal cloning and raising questions concerning its ethics.
A report from Newscientists.com argues that genes are disrupted when cultured in a lab, and this explains why so many cloned animals die or are grossly abnormal. On this account, it is not the cloning or IVF process that is at cause, but the culturing of the stem cells in the lab, creating major difficulties in cloning since so far there is no way around cloning through cultured cells in laboratory conditions.
A team of US scientists at the MIT Whitehead Institute examined 38 cloned mice and learned that even clones which look healthy suffer genetic maladies, as mice cloned from embryonic stem cells had abnormalities in the placenta, kidneys, heart, and liver. Scientists feared that the defective gene functioning in clones could, wreak havoc with organs and trigger foul-ups in the brain later in life and that embryonic stem cells are highly unstable. ‘‘There are almost no normal clones,’’ study author and MIT biology professor Rudolf Jaenisch, explained. Jaenisch claims that only 1%–5% of all cloned animals survive, and even those that survive to birth often have severe abnormalities and die prematurely.
As I argue below, these risks make human cloning a deeply problematic undertaking. Pro-cloning researchers argue that ‘‘glitches’’ in animal cloning eventually can be worked out. In January 2001, for example, researchers at Texas A&M University and the Roslin Institute claimed to have discovered a gene that causes abnormally large cloned fetuses, an insight they believe will allow them to predict and prevent this type of mutation. It is conceivable that might someday work out the “kinks,” but this assumes that science can master what arguably are inherent uncertainties and unpredictable variables in the expression of genes in a developing organism. A recent study showed that some mouse clones seem to develop normally until an age the equivalent of 30 years for a human being; then there is a spurt of growth and they suddenly become obese. Mark Westhusin, a cloning expert at Texas A&M, points out that the problem is not that of genetic mutation, but of ‘‘genetic expression,” such that genes are unstable and unpredictable in their functioning. Another report indicates that a few misplaced carbon atoms can lead to cloning failures. Thus, as developed in the postmodern mathematical paradigm of chaos theory, small errors in the cloning process could lead to huge disasters, and the prevention of all such ‘‘small errors’’ presumes a God-like omniscience scientists do not, and never will, possess.
Yet, while most scientists are opposed to cloning human beings (rather than stem cells), and decry it as ‘‘unacceptable,’’ few condemn the suffering caused to animals or position animal cloning research itself as morally problematic, and many scientists aggressively defend animal cloning. Blaatantly callous and unapologetically speciesist, Jaenisch, for example, proclaims, ‘‘You can dispose of these animals, but tell me—what do you do with abnormal humans?’’ The attitude that animals are disposable resources, things, or mere commodities rather than subjects of a life with inherent value and rights is a good indication of the problems inherent in the mechanistic scientific worldview (a theoretically disqualified relic of the seventeenth century) that still prevails despite the conceptual breakthroughs of chaos and complexity theory. to say nothing of the revolution in ethics that rejects speciesism as morally bankrupt and empirically false.
Despite the claims of its champions, the genetic engineering of animals is a radical departure from natural evolution and traditional forms of animal breeding. Genetic engineering involves manipulation of genes rather than whole organisms. Moreover, scientists engineer change at unprecedented rates, and can create novel beings across species boundaries that previously were unbridgeable. Ours is a world where cloned calves and sheep carry human genes, humanembryo cells are merged with enucleated cows’ eggs, monkeys, and rabbits are bred with jellyfish DNA, a surrogate horse gives birth to a zebra, a dairy cow spawns an endangered gaur, and tiger cubs emerge from the womb of an ordinary housecat.
The ability to clone a desired genetic type brings the animal kingdom into entirely new avenues of exploitation and commercialization. From the new scientific perspective, animals are framed as genetic information that can be edited, transposed, and copied endlessly. Pharming and xenotransplantation build on the system of factory farming that dates from the postwar period and is based on the confinement and intensive management of animals within enclosed buildings that are prison-houses of suffering.
The proclivity of the science-industrial complex to instrumentalize animals as nothing but resources for human use and profit intensifies in an era in which genetic engineering and cloning emergent as sources of immense profit and power. Still confined for maximal control, animals are no longer seen as whole species, but rather as fragments of genetic information to be manipulated for any purpose.
Weighty ethical and ecological concerns in the new modes of animal appropriation are largely ignored, as animals are still framed in the seventeenth century Cartesian worldview that sees them as non-sentient machines. As Rifkin (1998, 35) puts it, ‘‘Reducing the animal kingdom to customized, mass-produced replications of specific genotypes is the final articulation of the mechanistic, industrial frame of mind. A world where all life is transformed into engineering standards and made to conform to market values is a dystopian nightmare, and needs to be opposed by every caring and compassionate human being who believes in the intrinsic value of life.’’
Patenting of genetically modified animals has become a huge industry for multinational corporations and chemical companies. PPL Therapeutics, Genzyme Transgenics, Advanced Cell Technology, and other enterprises are issuing broad patent claims on methods of cloning non-human animals. PPL Therapeutics, the company that ‘‘invented’’ Dolly, has applied for the patents and agricultural rights to the production of all genetically altered mammals that could secrete therapeutic proteins in their milk. Nexia Biotechnologies obtained exclusive rights to all results from spider silk research. Patent number 4,736,866 was granted to Du Pont for Oncomouse, which the Patent Office described as a new ‘‘composition of matter.’’ Infigen holds a U.S. patent for activating human egg division through any means (mechanical, chemical, or otherwise) in the cloning process.
Certainly, genetics does not augur solely negative developments for animals. Given the reality of dramatic species extinction and loss of biodiversity, scientists are collecting the sperm and eggs of endangered species like the giant panda in order to preserve them in a ‘‘frozen zoo,’’ such as exists as San Diego Zoo. It is indeed exciting to ponder the possibilities of a Jurassic Park scenario of reconstructing extinct species (as, for example, scientists recently have uncovered the well-preserved remains of a Tasmanian tiger and a woolly mammoth). In October 2001, European scientists cloned a seemingly healthy mouflon lamb, a member of an endangered species of sheep. In April 2003, ACT produced the first successful interspecies clone when a dairy cow gave birth to a pair of bantengs, a species of wild cattle, cloned from an animal that died over 20 years ago. One of the pair, however, was thereafter euthanized because it was born twice the normal size and was suffering. Currently, working with preserved tissue samples, ACT is working to bring back from extinction the last bucardo mountain goat, which was killed by a falling tree in January 2000.
But critics dismiss these efforts as a misguided search for a technofix that distracts focus from the real problem of preserving habitat and biodiversity. Even if animals could be cloned, there is no way to replicate habitats lost forever to chainsaws, bulldozers and invading human armies. Moreover, the behaviors of cloned animals would unavoidably be altered and they would end up in zoos or exploitative entertainment settings, where they exist as spectacle and simulacra. Animals raised through interspecies cloning such as the gaur produced by ACT will not have the same disposition as if raised by their own species and so, for other reasons will not be less than ‘‘real.’’ Additionally, there is the likelihood that genetic engineering and cloning would aggravate biodiversity loss to the extent it creates monolithic super breeds that could crowd out other species or be easily wiped out by disease. There is also great potential for ecological disaster when new beings enter an environment, and genetically modified organisms are especially unpredictable in their behavior and effects.
Still, cloning may prove a valuable tool in preserving what can be salvaged from the current extinction crisis. Moreover, advances in genetics also may bypass and obviate pharming and xenotransplantation through use of stem cell technologies that clone human cells, tissues, or perhaps even entire organs and limbs from human embryos or an individual’s own cells. Successful stem cell technologies could eliminate at once the problem of immune rejection and the need for animals. There is also the intriguing possibility of developing medicines and vaccines in plants, rather than animals, thus producing a safer source of pharmaceuticals and neutraceuticals and sparing animals’ tremendous suffering. None of these promises, however, brighten the dark cloud cloning casts over the animal kingdom, or dispel the dangers of the dramatic alteration of agriculture and human life.
IV. Deferring the Brave New World: Challenges for Ethics and Democracy
Human history becomes more and more a race between education and catastrophe. – H.G. Wells
By summer of 2001, a technical and esoteric debate over stem cells, confined within the scientific community during the past years, had moved to the headlines to become the forefront of the ongoing science wars—battles over the cultural, ethical, and political implications of science (see Best and Kellner, 1997). The scientific debate over stem cell research in large part is a disguised culture war, and conservatives, liberals, and radicals have all jumped into the fray. Coming from a perspective of critical theory and radical democratic politics, I reject conservative theologies and argue against conflations of religion and the state. Likewise, I question neoliberal acceptance of corporate capitalism and underscore the implications of the privatization of research and the monopolization of knowledge and patents by huge biotech corporations. In addition, I urge a deeper level of public participation in science debates than do conservatives or liberals and believe that the public can be adequately educated to have meaningful and intelligent input into technical issues such as cloning and stem cell research that have tremendous human and ethical implications.
As I have shown, numerous issues are at stake in the debate over cloning, having to do not only with science, but also with religion, politics, economics, democracy, ethics, the meaning and nature of human beings, and of all species now subjected to genetic reconstruction. Thus, my goal throughout this paper has been to question the validity of the cloning project, particularly within the context of a global capitalist economy and its profit imperative, of a hubristic and reductionist modernist conceptual paradigm, and of a Western sensibility rooted on the will to power and the project of the domination of nature. Until science is recontextualized within a postmodern holistic paradigm informed by respect for living beings and complex organic processes, by democratic decision-making, and by a new ethic toward animals and the natural world, the genetic sciences on the whole are in the hands of those governed by the imperatives of profit. Moreover, politicians beholden to corporate interests have no grasp of the momentous issues involved, requiring that those interested in democratic politics and progressive social change must educate and involve themselves in the science and politics of biotechnology.
We have already entered a new stage of the postmodern adventure in which animal cloning is highly advanced and human cloning is on the horizon, if not now underway. Perhaps human clones are already emerging, with failures being discarded, as were the reportedly hundreds of botched attempts to create Louise Brown, the first test-tube baby, in 1978. At this stage, human cloning is indefensible given the high probability of creating monstrosities, the dangers to the mother, the burdens to society, the failure to reach a consensus on the viability and desirability of cloning humans, and the lack of compelling reasons to warrant this fateful move. The case is much different, however, for therapeutic cloning (i.e., stem cell regeneration technologies), which is incredibly promising and offers new hope for curing numerous debilitating diseases. But even stem cell research, and the cloning of human embryos is problematic, in part because it seems a real slippery slope toward reproductive cloning and mass production of desired types, which unavoidably will result in new modes of (genetic) hierarchical and new forms of discrimination, such as dramatized in the film Gattaca (1997).
We thus need intense discussion on the numerous issues involved in the shift to a posthuman, postbiological mode of existence where the boundaries between bodies and technologies, the natural and the artificial (never absolute in Homo sapiens, the technological species par excellance), radically erode as we morph toward a cyborg state. Technologies are no longer mere extensions of our bodies, as Marshall McLuhan argued in the 1960s, but rather are intimately merging with our bodies, as we implode not only with technology, machines, and computers, but also with other species through the genetic crossings involved in creating transgenic species. In an era of rapid flux, our genotypes, phenotypes, and identities are all rapidly mutating. Under the pressure of conceptual and and technological change, the humanist mode of understanding the self as a centered, rational subject has given way to new paradigms of communication, intersubjectivity. and hybridity (Hayles 1999), in addition to information and cybernetic models of understanding (Habermas 1979, 1984, 1987).
Despite these shifts, it is imperative that elements of the modern enlightenment tradition be retained, as it ,ust also be radicalized in post-mechanistic and posthumanist frameworks. Now more than ever, as science embarks on the bold and reckless projects of manipulating atoms and genes through nanotechnology, genetic engineering, and cloning, its awesome powers must be measured and tempered through ethical, ecological, and democratic norms in a process of public debate and participation. The walls between ‘‘experts’’ and ‘‘lay people’’ must be broken down along with the elitist norms that form their foundation. Scientists need to initiate dialogue with the public to discuss the complexities and dangers of new technosciences such as genetic engineering, cloning, and stem cell research, in order to make their positions clear and accessible, as well to be as accountable, transparent, and responsible. At the same time. public intellectuals, activists, and the citizenry in general need to become educated enough in the fundamental issues at stake in these rapidly unfolding revolutions in order to intelligently debate ethics and policy matters.
Scientists should recognize that their endeavors embody specific biases and value choices, subject them to critical scrutiny, and seek more humane, life-enhancing, and democratic values to guide their work. Respect for nature and life, preserving the natural environment, and serving human needs over corporate profits should be primary values embedded in science.
This approach is quite unlike how science so far has conducted itself in virtually all areas. Most blatantly, perhaps, scientists, hand-in-hand with corporations, have prematurely rushed the genetic revolution — the manipulation of agriculture, animals, and the world’s food supply — while ignoring crucial environmental, health, and ethical concerns. Immense power brings enormous responsibility, and it is time for scientists and technicians to awaken to this fact and make transparency and accountability integral to their ethos and research. A schizoid modern science that rigidly splits facts from values must give way to a postmodern metascience that grounds the production of knowledge in a social context of dialogue and communication with citizens.
The shift from a cold and detached ‘‘neutrality’’ to a participatory understanding of life that deconstructs the modern subject/object dichotomy; it derails realist claims to unmediated access to the world and opens the door to an empathetic and ecological understanding of nature (Keller 1983; Birke and Hubbard 1995). In place of a psuedo-objectivity that masks subservience to power and profit imperatives, technoscience must realize it is unavoidably bounded by ethics, values, ecology, and democratic norms at all times.
Thus, rather than working in total secrecy and shamelessly prostituting themselves to global corporations, scientists need to make democratic accountability and ethical responsibility core concerns, values, and practices in their work. As Bill Joy (2000) argued in a much-discussed Wired article, uncontrolled genetic technology, artificial intelligence, and nanotechnology could create catastrophic disasters, as well as utopian benefits. Joy’s article set off a firestorm of controversy, especially his call for government regulation of new technology and ‘‘relinquishment’’ of developing potentially dangerous new technologies such as genetic enginenering and nanontechnology. Joy warned that scientists and engineers should be very careful about the technologies they develop, as they may have catastrophic unforeseen consequences. Genetic engineering could create monstrous new species, while nanotechnology might build horrific ‘‘engines of destruction’’ as well as of the ‘‘engines of creation’’ envisioned by Eric Drexler (1987).
Science and technology, however, not only require responsibility and accountability on the part of scientists, but also regulation by government (so long as state-based societies exist) and democratic debate and participation by the public. To the extent possible, informed citizens need to be a critical part of the debate over technoscientific policies; rights, regulations, and responsibilities; and which forms of research have progressive potential and should be pursued, and which are dangerous and should never be undertaken. At the very least, there should be laws, guidelines, and regulatory agencies open to public input and scrutiny. To be rational and informed, citizens must be educated about the complexities of genetic engineering and cloning, a process that can unfold through vehicles such as public forums, teach-ins, and creative use of the open forums, broadcast media, and Internet. The Internet is a treasure-trove of information, ranging from informative sites such as the Council for Responsible Genetics (http://www.gene-watch.org) and The Institute of Science in Society (http://www.i-sis.org.uk), to lists serves hosted by progressive and democratic groups.
But to publicize and politicize biotechnology issues, social movements will have to take up issues like the cloning and stem cell debate into schools, media, social movements, and political struggles. Movements like the anti-nuclear coalitions and organized struggles against genetically modified foods have had major successes in educating the public, promoting debate, and influencing legislation in positive directions, such as stopping the FDA from diluting and debasing the meaning of “organic” to the point of allowing sludge and genetically modified foods to qualiy as “certified organic.” It will not do, however, to simply let the market decide what technologies will or will not be allowed, nor should bans be accepted on technologies that can benefit human life. Instead, citizens and those involved in social movements should engage issues of biotechnology and aid in public education and debate.
An intellectual revolution is needed to remedy the deficiencies in the education of both scientists and citizens, as such that each can have, in Habermas’ framework, ‘‘communicative competency’’ informed by sound value thinking, skills in reasoning, and democratic sensibilities. A Deweyean reconstruction of education would have scientists take more humanities and philosophy courses and engage ethical and political issues involved in the development and implementation of science and technology, and would have students in other fields take more science and technology courses to become literate in some of the major material and social forces of the epoch. C.P. Snow’s analysis (1959) of the ‘‘two cultures’’ problem provides a challenge for a democratic reconstruction of education to overcome in an increasing scientific and technological age that requires more and better knowledge of science and humanities.
Critical and self-reflexive scrutiny of scientific means, ends, and procedures should be a crucial part of the enterprise. ‘‘Critical,’’ in Haraway’s analysis, signifies ‘‘evaluative, public, multiactor, multiagenda, oriented to equality and heterogeneous well-being (Haraway 1997, 95).’’ Indeed, there should be debates concerning precisely what values are incorporated into specific scientific projects and whether these serve legitimate ends and goals. In the case of mapping the human genome, for instance, enormous amounts of money and energy are being spent, but almost no resources are going to educating the public about the ethical implications of having a genome map. The Human Genome Project spent only 3%–5% of its $3 billion budget on legal, ethical, and social issues, and Celera spent even less.
A democratic biopolitics and reconstruction of education would involve the emergence of new perspectives, understandings, sensibilities, values, and paradigms that put in question the assumptions, methods, values, and interpretations of modern sciences, calling for a reconstruction of science. At the same time, as science and technology co-construct each other, and both coevolve in conjunction with capitalist growth, profit, and power imperatives, science is reconstructing—not always for the better—the natural and social worlds, as well as our very identities and bodies. There is considerable ambiguity and tension in how science will play out given the different trajectories it can take. Unlike the salvationist promises of the technoscientific ideology and the apocalyptic dystopias of some of its critics, I see the future of science and technology to be entirely ambiguous, contested, and open. For now, the only certainty is that the juggernaut of the genetic revolution is rapidly advancing and that in the name of medical progress, animals are being victimized and exploited in new ways, while the replication and re-design of a plethora of species including human beings is looming.
Humanity is thus at a terribly difficult and complex crossroads. Whatever steps we take, it is imperative that we do not leave the decisions to the scientists, anymore than we would to the theologians (or corporate-hired bioethicists for that matter), for their judgment and objectivity is less than perfect, especially for the majority who are employed by biotechnology corporations and have a vested interest in the hastening and patenting of the brave new world of biotechnology. The issues involving genetics are so important that scientific, political, and moral debate must take place squarely within the public sphere. The fate of human beings, animals, and nature hangs in the balance, thus it is imperative that the public become informed on the latest developments and biotechnology and that lively and substantive democratic debate take place concerning the crucial issues raised by the new technosciences.
 Cited in Carey Goldberg, and Gina Kolata, ‘‘Scientists Announce Births of Cows Cloned in New Way.’’ The New York Times. January 21, 1998: A 14. Companies are now preparing to sell milk from cloned cows; see Jennifer Mitol, ‘‘Got cloned milk?’’ http://www.abcnews.com/ July 16, 2001. For the story of Dolly and animal cloning, see Kolata (1998).
 See Sheryl Gay Stolberg, ‘‘Breakthrough in Pig Cloning Could Aide Organ Transplants’’ (The New York Times, January 4, 2001). In July 2002, the Australian government announced draft guidelines that would regulate transplanting animal organs into humans and anticipated research with pig organs translated into humans within two years; see Benjamin Haslem, ‘‘Animal-to-human transplants get nod,’’ The Australian, July 8, 2002: A1
 See Heather Moore, ‘‘The Modern-Day Island of Dr, Moreau,’’ http://www.alternet.org/story.html?StoryID=11703, October 12, 2001. For a vivid description of the horrors of animal experimentation, see Singer (1975); for an acute diagnosis of the unscientific nature of vivisection,see Greek and Greek (2000).
 See ‘‘In Test, Japanese Have No Beef With Cloned Beef,’’ http://www.washingtonpost.com/wpsrv/inatl/daily/sept99/japan10.htm. According to one report, it is more accurate to refer to this beef as being produced by ‘‘embryo twinning,’’ and not the kind of cloning process that produced Dolly; see ‘‘‘Cloned’ Beef Scare Lacks Meat,’’ http://www.wired.com/news/technology/0,1282,19146,00.html. As just one indicator of the corporate will to clone animals for mass consumption, the National Institute of Science and Technology has donated $4.7 million to two industries to fund research into cloning chickens for food. See ‘‘Cloned chickens on the menu,’’ New Scientist.com, August 15, 2001.
 See Heather Moore, ‘‘The Modern-Day Island of Dr, Moreau,’’ op. cit., and Sharon Schmickle, ‘‘It’s what’s for dinner: milk and meat from clones,’’ http://www.startribune.com/stories/462/868271.html, December 2, 2001.
 ‘‘Clonefarm: Billions of identical chickens could soon be rolling off production lines,’’ http://www.newscientist.com/hottopics/cloning/cloning.jsp?id=23040300, August 18, 2001.
 Cited in Heather Moore, ‘‘The Modern Day Island of Dr. Moreau,’’ op. cit.
 ‘‘In Cloning, Failure Far Exceeds Success,’’ Gina Kolata, http://www.nytimes.com/2001/12/11/science/11CLON.html.
 See ‘‘Clones contain hidden DNA damage,’’ http://www.newscientist.com/news/news.-jsp?id=ns9999982; see also the study published in Science (July 6, 2001), which discusses why so many clone pregnancies fail and why some cloned animals suffer strange maladies in their hearts, joints, and immune system.
 ‘‘Clone Study Casts Doubt in Stem Cells: Variations in Mice Raise Human Research Issues,’’ http://www.washingtonpost.com/ac2/wp-dyn/A23967-2001Jul5?language= printer, July 6, 2001.
 See ‘‘Scientists Warn of Dangers of Human Cloning,’’ http://www.abcnews.com/. See also the commentaries in Gareth Cook, ‘‘Scientists say cloning may lead to long-term ills,’’ The Boston Globe, July 6, 2001; Steve Connor, ‘‘Human cloning will never be safe,’’ Independent, July 6, 2001; Carolyn Abraham, ‘‘Clone creatures carry genetic glitches,’’ July 6, 2001; Connor cites Dolly-cloner Ian Wilmut who noted: ‘‘It surely adds yet more evidence that there should be a moratorium against copying people. How can anybody take the risk of cloning a baby when its outcome is so unpredictable?’’
 See ‘‘Report Says Scientists See Cloning Problems‘‘, http://abcnews.go.com/wire.US/reuters200103525_573.html.
 Given this attitude, it is no surprise that in September, 2001, Texas AM University, the same institution working on cloning cats and dogs, showed off newly cloned pigs, who joined the bulls and goat already cloned by the school, as part of the ‘‘world’s first cloned animal fair.’’
 See ‘‘Back from the Brink: Cloning Endangered Species,’’ Pamela Weintraub, http://news.bmn.com/hmsbeagle/109/notes/ feature2, August 31, 2001. ‘‘Gene Find No Small Fetus,’’ http://www.wired.com/news/print/0,1294,41513,00.html
 See the collection of responses to Joy’s article in Wired 8.07 (July 2000). Agreeing with Joy that there need to be firm guidelines regulating nanotechnology, the Foresight Institute has written a set of guidelines for its development that take into account problems such as commercialization, unjust distribution of benefits, and potential dangers to the environment. See http://www.foresight.org/guidelines/current.html. I encourage such critical dialog on both the benefits and dangers of new technologies and hope to contribute to these debates with our studies.
 On ‘‘new science’’ and ‘‘new sensibilities,’’ see Herbert Marcuse, One-Dimensional Man (Beacon Press, Boston, 1964) and An Essay on Liberation (Beacon Press, Boston 1969).
 For a sharp critique of how bioethicists are bought off and co-opted by corporations in their bid for legitimacy, see ‘‘Bioethicists Fall Under Familiar Scrutiny,’’ http://www.nytimes.com/2001/08/02/health/genetics/02BIOE.html.
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